Jorja G. Henikoff

Position-based sequence weights

Amino acid substitution matrices from protein blocks.

Methods for alignment of protein sequences typically measure similarity by using a substitution matrix with scores for all possible exchanges of one amino acid with another. The...

Automated assembly of protein blocks for database searching

A system is described for finding and assembling the most highly conserved regions of related proteins for database searching. First, an automated version of Smith's algorithm f...

CUT&Tag for efficient epigenomic profiling of small samples and single cells

Many chromatin features play critical roles in regulating gene expression. A complete understanding of gene regulation will require the mapping of specific chromatin features in...

Integrative Analysis of the <i>Caenorhabditis elegans</i> Genome by the modENCODE Project

From Genome to Regulatory Networks For biologists, having a genome in hand is only the beginning—much more investigation is still needed to characterize how the genome is used t...