Max Planck Institute of Molecular Cell Biology and Genetics

The complete sequence of a human genome

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addr...

Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

Towards complete and error-free genome assemblies of all vertebrate species

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the collective intera...

Protein Phase Separation: A New Phase in Cell Biology

Cellular compartments and organelles organize biological matter. Most well-known organelles are separated by a membrane boundary from their surrounding milieu. There are also ma...

Accurate circular consensus long-read sequencing improves variant detection and assembly of a human genome

The DNA sequencing technologies in use today produce either highly accurate short reads or less-accurate long reads. We report the optimization of circular consensus sequencing ...

MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads

Background  PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb) and highly accurate (> Q20). Because of these properties, they have revolutionised genome assem...

Visualization of image data from cells to organisms

Advances in imaging techniques and high-throughput technologies are providing scientists with unprecedented possibilities to visualize internal structures of cells, organs and o...

Release and trafficking of lipid-linked morphogens