Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients

Abstract

This study demonstrates the relation among structural genomic alterations, molecular subtype, and clinical behavior and shows that an objective score of genomic complexity can provide independent prognostic information in breast cancer.

Keywords

Breast cancerComparative genomic hybridizationBiologyCancerComputational biologyGenomeOncologyMedicineGeneticsGene

MeSH Terms

Breast NeoplasmsChromosome AberrationsChromosomesHumanComparative Genomic HybridizationDisease ProgressionFemaleGene Expression ProfilingGene Expression RegulationNeoplasticGenomeHumanHumansPrognosisProportional Hazards Models

Affiliated Institutions

Related Publications

Genetic Signatures of HPV-related and Unrelated Oropharyngeal Carcinoma and Their Prognostic Implications

Jens Peter Klußmann , Jeroen J. Mooren , Martin Lehnen +10 more

Abstract Purpose: Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC....

2009 Clinical Cancer Research 204 citations

Inferring tumor progression from genomic heterogeneity

Nicholas E. Navin , Alexander Krasnitz , Linda Rodgers +13 more

Cancer progression in humans is difficult to infer because we do not routinely sample patients at multiple stages of their disease. However, heterogeneous breast tumors provide ...

2009 Genome Research 522 citations

Predicting the clinical status of human breast cancer by using gene expression profiles

Mike West , Carrie Blanchette , Holly K. Dressman +7 more

Prognostic and predictive factors are indispensable tools in the treatment of patients with neoplastic disease. For the most part, such factors rely on a few specific cell surfa...

2001 Proceedings of the National Academy o... 1335 citations

Network-based stratification of tumor mutations

Matan Hofree , John Paul Shen , Hannah Carter +2 more

Many forms of cancer have multiple subtypes with different causes and clinical outcomes. Somatic tumor genome sequences provide a rich new source of data for uncovering these su...

2013 Nature Methods 760 citations

Heterogeneity in Breast Cancer and the Problem of Relevance of Findings

Michaela Aubele , Martin Werner

Many attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a...

1999 Analytical Cellular Pathology 35 citations

Publication Info

Year: 2010
Type: article
Volume: 2
Issue: 38
Pages: 38ra47-38ra47
Citations: 153
Access: Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric

Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

153

OpenAlex

Influential

126

CrossRef

Cite This

APA Style

                            
                                
                                    Hege G. Russnes, 
                                
                                    Hans Kristian Moen Vollan, 
                                
                                    Ole Christian Lingjærde
                                
                                et al.
                            
                            (2010). 
                            Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients. 
                            Science Translational Medicine
                            , 2
                            (38)
                            , 38ra47-38ra47.
                            https://doi.org/10.1126/scitranslmed.3000611
                        

Identifiers

DOI: 10.1126/scitranslmed.3000611
PMID: 20592421
PMCID: PMC3972440

Data Quality

Data completeness: 86%