Abstract
Many attempts are made to identify critical genetic events responsible for the development and progression of breast cancer. There is increasing evidence that breast cancer is a heterogeneous disease, both, phenotypically as well as with respect to its molecular biologically. It is, therefore, extremely difficult to establish a diagnostically and prognostically relevant tumourigenesis model. Emerging new techniques such as microarrays, will provide us with a wealth of additional data over the next years. The precise sampling of tumour material in clearly defined histopathological lesions will be a prerequisite for the assignment of specific genetic alterations to defined stages of breast disease.
Keywords
Breast cancerDiseaseCancerBioinformaticsRelevance (law)DNA microarrayComputational biologyTumour heterogeneityMedicineBiologyPathologyGeneInternal medicineGeneticsGene expression
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Publication Info
- Year
- 1999
- Type
- review
- Volume
- 19
- Issue
- 2
- Pages
- 53-58
- Citations
- 35
- Access
- Closed
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Cite This
Michaela Aubele,
Martin Werner
(1999).
Heterogeneity in Breast Cancer and the Problem of Relevance of Findings.
Analytical Cellular Pathology
, 19
(2)
, 53-58.
https://doi.org/10.1155/1999/960923
Identifiers
- DOI
- 10.1155/1999/960923