Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

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Affiliated Institutions

• Science for Life Laboratory SE
• Institute of Genetics and Cancer GB
• University College Dublin IE
• University of Dundee GB
• Universitätsmedizin Greifswald DE
• Royal College of Surgeons in Ireland IE
• Johns Hopkins Medicine US
• University of Ioannina GR
• Memphis VA Medical Center US
• Ninewells Hospital GB
• King's College London GB
• Newcastle University GB
• University of Groningen NL
• Centro de Investigación en Red en Enfermedades Cardiovasculares ES
• VA Boston Healthcare System US
• Broad Institute US
• Icahn School of Medicine at Mount Sinai US
• IRCCS Materno Infantile Burlo Garofolo IT
• Karolinska Institutet SE
• University of Edinburgh GB
• National Human Genome Research Institute US
• Hunter Medical Research Institute AU
• University of Leicester GB
• Valley Health System US
• Centre for Human Genetics GB
• Imperial College London GB
• Emory Clinic US
• VA Palo Alto Health Care System US
• Center for Information Technology US
• University of Trieste IT
• Vrije Universiteit Amsterdam NL
• Institute for Biomedicine IT
• Malmö University SE
• VA Tennessee Valley Healthcare System US
• Brigham and Women's Hospital US
• Université de Lille FR
• University of Tennessee Health Science Center US
• University of Cambridge GB
• The University of Texas Health Science Center at Houston US
• Leiden University Medical Center NL
• Emory University US
• Indian Institute of Science Bangalore IN
• Lund University SE
• University of Oxford GB
• Eurac Research IT
• University Medical Center Groningen NL
• Erasmus MC NL
• Baylor College of Medicine US
• Western General Hospital GB
• Erasmus University Rotterdam NL
• Institute of Social and Preventive Medicine CH
• MRC Clinical Trials Unit at UCL GB
• National Institutes of Health US
• Bordeaux Population Health FR
• Inserm FR
• Stanford University US
• William Harvey Research Institute GB
• Atlanta VA Medical Center US
• Queen Mary University of London GB
• Institut Pasteur de Lille FR
• Université de Bordeaux FR
• University of Michigan US
• University of Lübeck DE
• MRC Epidemiology Unit GB
• Institute of Genetics and Biophysics IT
• Wellcome Sanger Institute GB
• University of Tartu EE
• McMaster University CA
• Johns Hopkins University US
• University of Washington US
• University Hospital of Lausanne CH
• Vanderbilt University Medical Center US
• Statistical Research (United States) US

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