Institute for Biomedicine - Academic Profile

Publications

A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization

Jack Bowden , Fabiola Del Greco M , Cosetta Minelli +3 more

Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent yea...

2017 Statistics in Medicine 1904 citations

Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome

Fabiola Del Greco M , Cosetta Minelli , Nuala A. Sheehan +1 more

Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an outcome by using genetic variants as instrumental variables, but its validity relies on the ...

2015 Statistics in Medicine 1733 citations

Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption

Jack Bowden , Fabiola Del Greco M , Cosetta Minelli +5 more

Abstract Background Two-sample summary data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for asse...

2017 bioRxiv (Cold Spring Harbor Laboratory) 100 citations

Institution Info

Type: facility
Country: IT
Publications: 3
Citations: 3,737

External Links

Identifiers

ROR: https://ror.org/02hsggv49