Discovery and refinement of loci associated with lipid levels
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for c...
Publications
View AllA framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization
Mendelian randomization (MR) uses genetic data to probe questions of causality in epidemiological research, by invoking the Instrumental Variable (IV) assumptions. In recent yea...
Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
Mendelian randomisation (MR) estimates causal effects of modifiable phenotypes on an outcome by using genetic variants as instrumental variables, but its validity relies on the ...
Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coro...
Improving the accuracy of two-sample summary data Mendelian randomization: moving beyond the NOME assumption
Abstract Background Two-sample summary data Mendelian randomization (MR) incorporating multiple genetic variants within a meta-analysis framework is a popular technique for asse...
Affiliated Researchers
Institution Info
- Type
- nonprofit
- Country
- IT
- Publications
- 5
- Citations
- 7,830
External Links
Identifiers
- ROR
- https://ror.org/01xt1w755