William Harvey Research Institute

The mutational constraint spectrum quantified from variation in 141,456 humans

Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the f...

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the r...

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Abstract Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to impr...

Discovery and refinement of loci associated with lipid levels

Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Common variants associated with plasma triglycerides and risk for coronary artery disease

Evaluating drug targets through human loss-of-function genetic variation