Evaluating drug targets through human loss-of-function genetic variation

Eric Vallabh Minikel , Konrad J. Karczewski , Hilary C. Martin , Eric Vallabh Minikel , Konrad J. Karczewski , Hilary C. Martin , Beryl B. Cummings , Nicola Whiffin , Daniel Rhodes , Jessica Alfoldi , Richard C. Trembath , David A. van Heel , Mark J. Daly , Genome Aggregation Database Production Team , Jessica Alfoldi , Irina M. Armean , Eric Banks , Louis Bergelson , Kristian Cibulskis , Ryan L. Collins , Kristen M. Connolly , Miguel Covarrubias , Mark J. Daly , Stacey Donnelly , Yossi Farjoun , Steven Ferriera , Laurent Francioli , Stacey Gabriel , Laura D. Gauthier , Jeff Gentry , Namrata Gupta , Thibault Jeandet , Diane Kaplan , Konrad J. Karczewski , Kristen M. Laricchia , Christopher Llanwarne , Eric V. Minikel , Ruchi Munshi , Benjamin M. Neale , Sam Novod , Anne H. O’Donnell-Luria , Nikelle Petrillo , Timothy Poterba , David Roazen , Valentin Ruano-Rubio , Andrea Saltzman , Kaitlin E. Samocha , Molly Schleicher , Cotton Seed , Matthew Solomonson , Jose Soto , Grace Tiao , Kathleen Tibbetts , Charlotte Tolonen , Christopher Vittal , Gordon Wade , Arcturus Wang , Qingbo Wang , James S. Ware , Nicholas A. Watts , Ben Weisburd , Genome Aggregation Database Consortium , Carlos A. Aguilar Salinas , Tariq Ahmad , Christine M. Albert , Diego Ardissino , Gil Atzmon , John Barnard , Laurent Beaugerie , Emelia J. Benjamin , Michael Boehnke , Lori L. Bonnycastle , Erwin P. Bottinger , Donald W. Bowden , Matthew J Bown , John C. Chambers , JULIANA C. CHAN , Daniel Chasman , Judy Cho , Mina K. Chung , Bruce Cohen , Adolfo Correa , Dana Dabelea , Dawood Darbar , Ravindranath Duggirala , Josée Dupuis , Patrick T. Ellinor , Roberto Elosua , Jeanette Erdmann , Tõnu Esko , Martti Färkkilä , José Flórez , Andre Franke , Gad Getz , Benjamin Glaser , Stephen J Glatt , David Goldstein , Clicerio Gonzalez , Leif Groop , Christopher Haiman , Craig Hanis , Matthew Harms , Mikko Hiltunen
2020 Nature 167 citations

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Year
2020
Type
article
Volume
581
Issue
7809
Pages
459-464
Citations
167
Access
Closed

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Eric Vallabh Minikel, Konrad J. Karczewski, Hilary C. Martin et al. (2020). Evaluating drug targets through human loss-of-function genetic variation. Nature , 581 (7809) , 459-464. https://doi.org/10.1038/s41586-020-2267-z

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DOI
10.1038/s41586-020-2267-z