Centro de Investigación Biomédica en Red

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), ...

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

BACKGROUND Nivolumab plus ipilimumab or nivolumab alone resulted in longer progression-free and overall survival than ipilimumab alone in a trial involving patients with advance...

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Faulty blood cells and heart disease Recent studies have shown that elderly people's blood cells often harbor mutations in genes encoding certain epigenetic regulators. These mu...

Quantifying prion disease penetrance using large population control cohorts

Large genomic reference data sets reveal a spectrum of pathogenicity in the prion protein gene and provide genetic validation for a therapeutic strategy in prion disease.

Evaluating drug targets through human loss-of-function genetic variation