Publications
View AllThe mutational constraint spectrum quantified from variation in 141,456 humans
Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial for the f...
Characterizing the Epidemiological Transition in Mexico: National and Subnational Burden of Diseases, Injuries, and Risk Factors
Mexico is at an advanced stage in the epidemiologic transition, with the majority of the disease and injury burden from noncommunicable diseases. A unique characteristic of the ...
Characterising the loss-of-function impact of 5’ untranslated region variants in 15,708 individuals
Abstract Upstream open reading frames (uORFs) are tissue-specific cis -regulators of protein translation. Isolated reports have shown that variants that create or disrupt uORFs ...
The effect of LRRK2 loss-of-function variants in humans
Abstract Human genetic variants predicted to cause loss-of-function of protein-coding genes (pLoF variants) provide natural in vivo models of human gene inactivation and can be ...
Burden of disease assessment and health system reform: Results of a study in Mexico
Abstract This paper describes in broad terms the first national assessment of the burden of disease using Disability Adjusted Life Years, which formed part of an overall study o...
Affiliated Researchers
Institution Info
- Type
- government
- Country
- MX
- Publications
- 9
- Citations
- 19,983
External Links
Identifiers
- ROR
- https://ror.org/032y0n460