Abstract
To assess the possible modulatory effects of insulin-like growth factor-1 (IGF-1) on the brain effects of proinflammatory cytokines, male CD-1 mice were injected into the lateral ventricle of the brain with a behaviorally depressing dose (100 ng) of the cytokine inducer lipopolysaccharide (LPS) and their response to various doses of IGF-1 (0, 100 and 1000 ng) was measured during behavioral tests carried before and at various time intervals after treatment. LPS induced a profound behavioral depression that was abrogated by the higher dose of IGF-1 tested. Since the behavioral effects of LPS are mediated by the local synthesis and results of proinflammatory cytokines, these results indicate that IGF-1 interferes with the production and/or action of proinflammatory cytokines in the brain.
Keywords
Sickness behaviorProinflammatory cytokineLipopolysaccharideInsulin-like growth factorEndocrinologyInternal medicineCytokineCentral nervous systemMedicineGrowth factorInflammationReceptor
MeSH Terms
AnimalsBehaviorAnimalBrainDose-Response RelationshipDrugExploratory BehaviorInjectionsIntraventricularInsulin-Like Growth Factor ILipopolysaccharidesMaleMiceMiceInbred StrainsMotor ActivitySexual BehaviorAnimalTime Factors
Affiliated Institutions
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Publication Info
- Year
- 1999
- Type
- article
- Volume
- 10
- Issue
- 2
- Pages
- 289-292
- Citations
- 54
- Access
- Closed
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Cite This
Robert Dantzer,
Gilles Gheusi,
Rodney W. Johnson
et al.
(1999).
Central administration of insulin-like growth factor-1 inhibits lipopolysaccharide-induced sickness behavior in mice.
Neuroreport
, 10
(2)
, 289-292.
https://doi.org/10.1097/00001756-199902050-00015
Identifiers
- DOI
- 10.1097/00001756-199902050-00015
- PMID
- 10203323