Abstract

Several inflammatory cytokines, most notably tumor necrosis factor (TNF) and IL-1, induce anorexia and loss of lean body mass, common manifestations of acute and chronic inflammatory conditions. In C57BL/6 female mice, the administration of TNF, IL-1, and, to a lesser extent, leukemia inhibitory factor (LIF), produced a prompt and dose-dependent increase in serum leptin levels and leptin mRNA expression in fat. IL-10, IL-4, ciliary neurotrophic factor, and IL-2, cytokines not known to induce anorexia or decrease food intake, had no effect on leptin gene expression or serum leptin levels. After administration of Escherichia coli lipopolysaccharide (LPS), leptin gene expression and leptin levels were increased. These findings suggest that leptin levels may be one mechanism by which anorexia is induced during acute inflammatory conditions.

Keywords

LeptinAnorexiaEndocrinologyInternal medicineLeukemia inhibitory factorTumor necrosis factor alphaInflammationLipopolysaccharideProinflammatory cytokineMedicineCytokineInterleukin 6Obesity

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Year
1997
Type
article
Volume
185
Issue
1
Pages
171-176
Citations
790
Access
Closed

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Pasha Sarraf, Robert Frederich, Ewa M. Turner et al. (1997). Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia. The Journal of Experimental Medicine , 185 (1) , 171-176. https://doi.org/10.1084/jem.185.1.171

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DOI
10.1084/jem.185.1.171