Beth Israel Deaconess Hospital

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor ce...

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

We have identified several mechanisms by which the angiogenic cytokine vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) likely regulates endothelial ce...

Comorbidities, complications, and coding bias. Does the number of diagnosis codes matter in predicting in-hospital mortality?

Bias against coding of chronic or comorbid conditions on the computerized discharge abstracts of patients who die best explains these results. Efforts to improve diagnosis codin...

Predicting Who Dies Depends on How Severity Is Measured: Implications for Evaluating Patient Outcomes

Some pairs of severity measures assigned very different severity levels to more than 20% of patients. Evaluations of patient outcomes need to be sensitive to the severity measur...

Physiological identification of GABA as the inhibitory transmitter for mammalian cortical neurons in cell culture

(1) Rat cortical neurons grown in dissociated cell culture exhibit IPSPs which appear to be generated by an increase in membrane conductance to chloride. (2) The neurons are all...

Point mutations impairing cell surface expression of the common beta subunit (CD18) in a patient with leukocyte adhesion molecule (Leu-CAM) deficiency.

The leukocyte adhesion molecules CD11a/CD18, CD11b/CD18, and CD11c/CD18 (Leu-CAM) are members of the integrin receptor family and mediate crucial adhesion-dependent functions in...

Severity Measurement Methods and Judging Hospital Death Rates for Pneumonia

Payers and policymakers are increasingly examining hospital mortality rates as indicators of hospital quality. To be meaningful, these death rates must be adjusted for patient s...

The record of independent living

This paper describes the Record of Independent Living, a new measure of activities of daily living specifically designed for the evaluation of elderly patients experiencing cogn...