Abstract
In this review we discuss the concept of anti-angiogenesis, which is the inhibition of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on various elements of the angiogenic process, including induction of vascular discontinuity, endothelial cell movement, endothelial cell proliferation, and three-dimensional restructuring of patent vessels. An effort is made to place the many different approaches to anti-angiogenesis research into a comprehensible structure, in order to identify problems of evaluation and interpretation, thereby providing a clearer basis for determining promising and needed directions for further investigation.
Keywords
AngiogenesisNeovascularizationEndothelial stem cellComputational biologyNeuroscienceCell biologyComputer scienceBiologyCancer researchIn vitroBiochemistry
MeSH Terms
AnimalsBasement MembraneCell CommunicationCell DivisionCell MovementEndotheliumVascularHumansNeovascularizationPathologic
Affiliated Institutions
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Publication Info
- Year
- 1994
- Type
- review
- Volume
- 63
- Issue
- 3
- Pages
- 265-311
- Citations
- 319
- Access
- Closed
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Cite This
Wanda Auerbach,
Robert Auerbach
(1994).
Angiogenesis inhibition: A review.
Pharmacology & Therapeutics
, 63
(3)
, 265-311.
https://doi.org/10.1016/0163-7258(94)90027-2
Identifiers
- DOI
- 10.1016/0163-7258(94)90027-2
- PMID
- 7530374