Abstract

Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.

Keywords

AngiogenesisProgenitor cellHeterologousCell biologyEndothelial stem cellBiologyEndothelial progenitor cellTherapeutic angiogenesisIn vitroImmunologyNeovascularizationStem cellCancer researchBiochemistry

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Publication Info

Year
1997
Type
article
Volume
275
Issue
5302
Pages
964-966
Citations
8674
Access
Closed

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Takayuki Asahara, Toyoaki Murohara, Alison Sullivan et al. (1997). Isolation of Putative Progenitor Endothelial Cells for Angiogenesis. Science , 275 (5302) , 964-966. https://doi.org/10.1126/science.275.5302.964

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DOI
10.1126/science.275.5302.964