Abstract

Leukocyte-endothelial adhesion and angiogenesis, until recently considered as separate processes, have been shown to be linked by two recent findings: soluble cellular adhesion molecules (CAMs) involved in leukocyte-endothelial interactions are angiogenic and well known angiogenic molecules secreted by cancer or immune. cells can modulate the endothelial CAMs. This molecular link may partially explain why the overall leukocyte-endothelial interaction is often low and heterogeneous in angiogenic tumor vessels and why activated lymphocytes adhere nonuniformly to tumor vessels when injected into the tumor's blood supply.

Keywords

AngiogenesisCell adhesion moleculeEndothelial stem cellAdhesionImmune systemCell biologyNeovascularizationEndotheliumBiologyImmunologyCancer researchChemistryIn vitroBiochemistryEndocrinology

MeSH Terms

AnimalsCell AdhesionCell Adhesion MoleculesCell CommunicationEndotheliumVascularHumansLeukocytesNeoplasmsNeovascularizationPathologic

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Publication Info

Year
1996
Type
review
Volume
15
Issue
2
Pages
195-204
Citations
107
Access
Closed

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Cite This

Rakesh K. Jain, Gerald Koenig, Marc Dellian et al. (1996). Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer and Metastasis Reviews , 15 (2) , 195-204. https://doi.org/10.1007/bf00437472

Identifiers

DOI
10.1007/bf00437472
PMID
8842491

Data Quality

Data completeness: 81%