Walter Fiers

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

Abstract Recombinant human tumour necrosis factor (rhTNF) had anti‐tumour activity against 2 of 3 human ovarian cancer xenografts growing intraperitonealy (i.p.) in nude mice, p...

Preferential codon usage in prokaryotic genes: the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes

Tumor necrosis factor Characterization at the molecular, cellular and in vivo level

TNF was originally characterized as an antitumor agent and a factor cytotoxic for many malignant cells. It is now clear that it plays an important role in the defense against vi...

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

Human recombinant tumor necrosis factor (rTNF) was found to act directly on cultured human vascular endothelium to induce a tissue factor-like procoagulant activity (PCA). After...