The Honourable Society of Lincoln's Inn

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

HOW CELLS RESPOND TO INTERFERONS

Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct. They involve tyro...

More Informative Abstracts Revisited

Following proposals in 1987 and 1988, several medical journals have provided more informative abstracts ("structured abstracts") for articles of clinical interest. Structured ab...

Changes in keratinocyte adhesion during terminal differentiation: Reduction in fibronectin binding precedes α5β1 integrin loss from the cell surface

Fibronectin inhibits the terminal differentiation of human keratinocytes

Bootstrap investigation of the stability of a cox regression model

Abstract We describe a bootstrap investigation of the stability of a Cox proportional hazards regression model resulting from the analysis of a clinical trial of azathioprine ve...

β-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

ABSTRACT We found that cultured human keratinocytes with high proliferative potential, the putative epidermal stem cells, expressed a higher level of noncadherin-associated β- c...

Practical problems in fitting a proportional hazards model to data with udated measurements of the covariates

Abstract We review and discuss the practical problems encountered when analysing the effect on survival of covariates which are measured repeatedly over time. Specific issues ar...