Orit Rozenblatt–Rosen

Single-cell transcriptomics to explore the immune system in health and disease

The immune system varies in cell types, states, and locations. The complex networks, interactions, and responses of immune cells produce diverse cellular ecosystems composed of ...

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Intra- and Inter-cellular Rewiring of the Human Colon during Ulcerative Colitis

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma

Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains challenging. Her...

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Single-cell expression profiles of melanoma Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh et al. ...