A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Keywords

BiologyBlockadeCancerCancer researchCellResistance (ecology)Cell biologyGeneticsReceptor

Affiliated Institutions

Related Publications

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

Matthew M. Gubin , Xiuli Zhang , Heiko Schuster +24 more

The immune system influences the fate of developing cancers by not only functioning as a tumour promoter that facilitates cellular transformation, promotes tumour growth and scu...

2014 Nature 1936 citations

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

Michael A. Curran , Welby Montalvo , Hideo Yagita∥ +1 more

Vaccination with irradiated B16 melanoma cells expressing either GM-CSF (Gvax) or Flt3-ligand (Fvax) combined with antibody blockade of the negative T-cell costimulatory recepto...

2010 Proceedings of the National Academy o... 1833 citations

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

Valsamo Anagnostou , Kellie N. Smith , Patrick M. Forde +26 more

Abstract Immune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load. We have examined the ...

2016 Cancer Discovery 853 citations

Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence

Raju Vaddepally , Prakash Kharel , Ramesh Kumar Pandey +2 more

Cancer is associated with higher morbidity and mortality and is the second leading cause of death in the US. Further, in some nations, cancer has overtaken heart disease as the ...

2020 Cancers 1138 citations

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang , Michael D. Green , Jae Eun Choi +27 more

Cancer immunotherapy restores or enhances the effector function of CD8+ T cells in the tumour microenvironment1,2. CD8+ T cells activated by cancer immunotherapy clear tumours m...

2019 Nature 2612 citations

Publication Info

Year: 2018
Type: article
Volume: 175
Issue: 4
Pages: 984-997.e24
Citations: 1317
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1317

OpenAlex

Cite This

APA Style

                            
                                
                                    Livnat Jerby‐Arnon, 
                                
                                    Parin Shah, 
                                
                                    Michael S. Cuoco
                                
                                et al.
                            
                            (2018). 
                            A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. 
                            Cell
                            , 175
                            (4)
                            , 984-997.e24.
                            https://doi.org/10.1016/j.cell.2018.09.006
                        

Identifiers

DOI: 10.1016/j.cell.2018.09.006