Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Abstract

Single-cell expression profiles of melanoma Tumors harbor multiple cell types that are thought to play a role in the development of resistance to drug treatments. Tirosh et al. used single-cell sequencing to investigate the distribution of these differing genetic profiles within melanomas. Many cells harbored heterogeneous genetic programs that reflected two different states of genetic expression, one of which was linked to resistance development. Following drug treatment, the resistance-linked expression state was found at a much higher level. Furthermore, the environment of the melanoma cells affected their gene expression programs. Science , this issue p. 189

Keywords

Affiliated Institutions

• Brigham and Women's Hospital US
• Massachusetts General Hospital US
• Dana-Farber Cancer Institute US
• Center for Systems Biology US
• Harvard University US
• IIT@MIT US
• Broad Institute US
• Howard Hughes Medical Institute US
• Ragon Institute of MGH, MIT and Harvard US
• QIMR Berghofer Medical Research Institute AU
• Massachusetts Institute of Technology US

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