Carl Nathan

Metchnikoff's Legacy in 2008

Production of large amounts of hydrogen peroxide by human tumor cells.

Few nonphagocytic cells are known to generate reactive oxygen intermediates. Based on horseradish peroxidase-dependent, catalase-inhibitable oxidation of fluorescent scopoletin,...

Role of nitric oxide synthesis in macrophage antimicrobial activity

Macrophage deactivation by interleukin 10.

Recombinant mouse interleukin 10 (IL-10) was exceedingly potent at suppressing the ability of mouse peritoneal macrophages (m phi) to release tumor necrosis factor alpha (TNF-al...

Neutrophils and immunity: challenges and opportunities

Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have...

Points of control in inflammation

Inflammation is a complex set of interactions among soluble factors and cells that can arise in any tissue in response to traumatic, infectious, post-ischaemic, toxic or autoimm...

Deactivation of macrophages by transforming growth factor-β

Macrophage activation--enhanced capacity to kill, in a cell that otherwise mostly scavenges--is essential for host survival from infection and contributes to containment of tumo...

Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and <i>Mycobacterium tuberculosis</i>

Macrophage activation determines the outcome of infection by Mycobacterium tuberculosis (Mtb). Interferon-γ (IFN-γ) activates macrophages by driving Janus tyrosine kinase (JAK)/...