Abstract
Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lymphohaematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.
Keywords
ImmunologyImmunityImmune systemHematologyRheumatologyInfectious disease (medical specialty)DiseaseBiologyMedicinePathologyInternal medicine
MeSH Terms
AnimalsCalciumHumansImmunityLeukosialinNeutrophilsPeroxidaseSignal TransductionWound Healing
Affiliated Institutions
Related Publications
The phagocytes: neutrophils and monocytes
Abstract The production and deployment of phagocytes are central functions of the hematopoietic system. In the 1950s, radioisotopic studies demonstrated the high prodution rate ...
Publication Info
- Year
- 2006
- Type
- review
- Volume
- 6
- Issue
- 3
- Pages
- 173-182
- Citations
- 2868
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2868
OpenAlex
119
Influential
2273
CrossRef
Cite This
Carl Nathan
(2006).
Neutrophils and immunity: challenges and opportunities.
Nature reviews. Immunology
, 6
(3)
, 173-182.
https://doi.org/10.1038/nri1785
Identifiers
- DOI
- 10.1038/nri1785
- PMID
- 16498448