Bruce N. Ames

The Free Radical Theory of Aging Matures

Beckman, Kenneth B., and Bruce N. Ames. The Free Radical Theory of Aging Matures. Physiol. Rev. 78: 547–581, 1998. — The free radical theory of aging, conceived in 1956, has tur...

Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens

Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N -hydroxy-2-aminofluorene, are potent frameshift mutagens for Salmon...

Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test

COORDINATE REPRESSION OF THE SYNTHESIS OF FOUR HISTIDINE BIOSYNTHETIC ENZYMES BY HISTIDINE

Understanding household behavior and its macro consequences for society is pivotal for climate change adaptation. Yet, traditional policy decision-support models for nature–soci...

Oxygen Radicals and Human Disease

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles...

Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection

18 Carcinogens, including aflatoxin B 1 , benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino- trans -stilbene, are shown to be activated by liver homogenates to f...

A SIMPLE METHOD FOR DETECTING ENVIRONMENTAL CARCINOGENS AS MUTAGENS*

Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens

K-region epoxides of the carcinogens benz [a] anthracene, dibenz [ a , h ]anthracene, and 7-methylbenz [a] anthracene are mutagenic in strains of Salmonella typhimurium designed...

Revised methods for the Salmonella mutagenicity test

Cancer prevention and diet: Help from single nucleotide polymorphisms

Understanding a visual scene is an unsolved and daunting task, since scenes can contain a large number of objects, their properties, and interrelations. Extracting the full scen...