Oxygen Radicals and Human Disease

Carroll E. Cross; Barry Halliwell; Edward T. Borish; William A. Pryor; Bruce N. Ames; Robert L. Saul; Joe M. McCord; Denham Harman

doi:10.7326/0003-4819-107-4-526

Abstract

Toxic oxygen free radicals have been implicated as important pathologic mediators in many clinical disorders. We discuss the chemistry of oxygen radical production and the roles of iron and of various antioxidants as well as the diseases that have received active attention in oxyradical research. Particular attention is focused on cigarette smoke oxidants, ischemia-reperfusion-induced radical production, carcinogenesis, and aging. Such research may well provide a firm foundation for therapeutic breakthroughs.

Keywords

MedicineRadicalCigarette smokeOxygenActive oxygenDiseaseReactive oxygen speciesBiochemistryPathologyChemistryEnvironmental health

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Publication Info

Year: 1987
Type: review
Volume: 107
Issue: 4
Pages: 526-545
Citations: 1848
Access: Closed

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APA Style

                            
                                
                                    Carroll E. Cross, 
                                
                                    Barry Halliwell, 
                                
                                    Edward T. Borish
                                
                                et al.
                            
                            (1987). 
                            Oxygen Radicals and Human Disease. 
                            Annals of Internal Medicine
                            , 107
                            (4)
                            , 526-545.
                            https://doi.org/10.7326/0003-4819-107-4-526
                        

Identifiers

DOI: 10.7326/0003-4819-107-4-526