Abstract
Several carcinogenic metabolites of the carcinogen 2-acetyl-aminofluorene, especially 2-nitrosofluorene and N -hydroxy-2-aminofluorene, are potent frameshift mutagens for Salmonella typhimurium . 2-Nitrosonaphthalene, 2-nitrosophenanthrene, 4-nitroso- trans -stilbene, 4-nitrosobiphenyl, and 4-nitrosoazobenzene, all of which are metabolites or likely metabolites of carcinogenic aromatic amines, are also potent frameshift mutagens. These compounds may be frameshift mutagens of the class that intercalates into DNA and then reacts covalently with the DNA; various ultimate carcinogens may be of this type. The utility of a set of bacterial strains for detecting carcinogens as mutagens is shown.
Keywords
CarcinogenFrameshift mutationChemistryDNAAromatic amineAmes testBiochemistrySalmonellaMutationOrganic chemistryBiologyGeneticsBacteria
Affiliated Institutions
Related Publications
Carcinogens are Mutagens: A Simple Test System Combining Liver Homogenates for Activation and Bacteria for Detection
18 Carcinogens, including aflatoxin B 1 , benzo(a)pyrene, acetylaminofluorene, benzidine, and dimethylamino- trans -stilbene, are shown to be activated by liver homogenates to f...
Chemical Carcinogens as Frameshift Mutagens: <i>Salmonella</i> DNA Sequence Sensitive to Mutagenesis by Polycyclic Carcinogens
Other investigators have shown that several polycyclic carcinogens are frameshift mutagens in Salmonella . Mutagenic potency of these compounds is assessed by ability to induce ...
Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens
K-region epoxides of the carcinogens benz [a] anthracene, dibenz [ a , h ]anthracene, and 7-methylbenz [a] anthracene are mutagenic in strains of Salmonella typhimurium designed...
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence
Epidemiological studies have shown that exposure to diesel exhaust and urban air pollution is associated with an increased risk of lung cancer. 3-Nitrobenzanthrone [3-nitro-7H-b...
Toxic Effects of the Major Components of Diesel Exhaust in Human Alveolar Basal Epithelial Cells (A549)
We investigated the toxicity of benzo[a]pyrene (B[a]P), 1-nitropyrene (1-NP) and 3-nitrobenzanthrone (3-NBA) in A549 cells. Cells were treated for 4 h and 24 h with: B[a]P (0.1 ...
Publication Info
- Year
- 1972
- Type
- article
- Volume
- 69
- Issue
- 11
- Pages
- 3128-3132
- Citations
- 367
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
367
OpenAlex
Cite This
Bruce N. Ames,
E G Gurney,
James A. Miller
et al.
(1972).
Carcinogens as Frameshift Mutagens: Metabolites and Derivatives of 2-Acetylaminofluorene and Other Aromatic Amine Carcinogens.
Proceedings of the National Academy of Sciences
, 69
(11)
, 3128-3132.
https://doi.org/10.1073/pnas.69.11.3128
Identifiers
- DOI
- 10.1073/pnas.69.11.3128