Adrian Bird

Use of restriction enzymes to study eukaryotic DNA methylation

DNA methylation patterns and epigenetic memory

The character of a cell is defined by its constituent proteins, which are the result of specific patterns of gene expression. Crucial determinants of gene expression patterns ar...

CpG-rich islands and the function of DNA methylation

Methylation-Induced Repression— Belts, Braces, and Chromatin

Number of CpG islands and genes in human and mouse.

Estimation of gene number in mammals is difficult due to the high proportion of noncoding DNA within the nucleus. In this study, we provide a direct measurement of the number of...

High levels of De Novo methylation and altered chromatin structure at CpG islands in cell lines

Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl-CpG binding protein.

Gene number, noise reduction and biological complexity

CpG islands as gene markers in the vertebrate nucleus

CpG islands as genomic footprints of promoters that are associated with replication origins

Non-methylated CpG-rich islands at the human alpha-globin locus: implications for evolution of the alpha-globin pseudogene.

Methylated and unmethylated DNA compartments in the sea urchin genome

Does DNA methylation control transposition of selfish elements in the germline?

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

CpG islands (CGIs) are dense clusters of CpG sequences that punctuate the CpG-deficient human genome and associate with many gene promoters. As CGIs also differ from bulk chromo...

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

CpG islands – ‘A rough guide’

Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associa...