Keywords
Affiliated Institutions
Related Publications
Gene Silencing in Cancer in Association with Promoter Hypermethylation
This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key...
Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression
Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this fun...
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
Here we describe the cloning and characterization of a PAS domain transcription factor termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia i...
Tissue‐specific dysregulation of DNA methylation in aging
Summary The normal aging process is a complex phenomenon associated with physiological alterations in the function of cells and organs over time. Although an attractive candidat...
Publication Info
- Year
- 1992
- Type
- article
- Volume
- 11
- Issue
- 1
- Pages
- 327-333
- Citations
- 473
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1002/j.1460-2075.1992.tb05055.x