Genome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly...
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AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
Abstract The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure pred...
Laplacian Eigenmaps for Dimensionality Reduction and Data Representation
One of the central problems in machine learning and pattern recognition is to develop appropriate representations for complex data. We consider the problem of constructing a rep...
The Population Ecology of Organizations
A population ecology perspective on organization-environment relations is proposed as an alternative to the dominant adaptation perspective. The strength of inertial pressures o...
The Complete Genome Sequence of <i>Escherichia coli</i> K-12
The 4,639,221–base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five othe...
Proposed Experiment to Test Local Hidden-Variable Theories
A theorem of Bell, proving that certain predictions of quantum mechanics are inconsistent with the entire family of local hidden-variable theories, is generalized so as to apply...