AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

Abstract

Abstract The AlphaFold Protein Structure Database (AlphaFold DB, https://alphafold.ebi.ac.uk) is an openly accessible, extensive database of high-accuracy protein-structure predictions. Powered by AlphaFold v2.0 of DeepMind, it has enabled an unprecedented expansion of the structural coverage of the known protein-sequence space. AlphaFold DB provides programmatic access to and interactive visualization of predicted atomic coordinates, per-residue and pairwise model-confidence estimates and predicted aligned errors. The initial release of AlphaFold DB contains over 360,000 predicted structures across 21 model-organism proteomes, which will soon be expanded to cover most of the (over 100 million) representative sequences from the UniRef90 data set.

Keywords

BiologyPairwise comparisonSequence (biology)DatabaseVisualizationProtein structureComputational biologyProteomeBioinformaticsComputer scienceData miningGeneticsArtificial intelligence

MeSH Terms

Amino Acid SequenceAnimalsBacteriaDatabasesProteinDatasets as TopicDictyosteliumFungiHumansInternetModelsMolecularPlantsProtein Conformationalpha-HelicalProtein Conformationbeta-StrandProtein FoldingProteinsSoftwareTrypanosoma cruzi

Affiliated Institutions

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Publication Info

Year: 2021
Type: article
Volume: 50
Issue: D1
Pages: D439-D444
Citations: 7525
Access: Closed

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APA Style

                            
                                
                                    Mihály Váradi, 
                                
                                    Stephen Anyango, 
                                
                                    Mandar Deshpande
                                
                                et al.
                            
                            (2021). 
                            AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. 
                            Nucleic Acids Research
                            , 50
                            (D1)
                            , D439-D444.
                            https://doi.org/10.1093/nar/gkab1061
                        

Identifiers

DOI: 10.1093/nar/gkab1061
PMID: 34791371
PMCID: PMC8728224

Data Quality

Data completeness: 90%