Neuropathology of synuclein aggregates
Beginning with the isolation of the fragment of alpha-synuclein (alpha-syn) known as the non-Abeta component of amyloid plaques (NAC peptide) from Alzheimer's disease (AD) brain...
Publications
Explore 82 academic publications
Showing 12 of
82 publications
UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer
The UK Lung Screen (UKLS) is a randomised controlled trial of the use of low-dose multidetector CT for lung cancer screening. It completed the Health Technology Appraisal (HTA)-...
CONCENTRIC HYALIN INTRANEURONAL INCLUSIONS OF LEWY TYPE IN THE BRAINS OF ELDERLY PERSONS (50 INCIDENTAL CASES): RELATIONSHIP TO PARKINSONISM
A bstract The significance of the intracytoplasmic hyalin neuronal inclusions first described by Lewy over fifty years ago is discussed on the basis of an analysis of 50 autopsy...
Defining Molecular Targets to Prevent Alzheimer Disease
An explosion of new techniques to explore DNA and protein biology during the last 2 decades has illuminated one of the most enigmatic and intractable subjects in biomedicine—neu...
Influence of sex on expansion rate of abdominal aortic aneurysms
Abstract Background The UK Small Aneurysm Trial suggested that female sex is an independent risk factor for rupture of abdominal aortic aneurysm (AAA). This study assessed the e...
Clinical and Pathological Aspects of Parkinsonism in Alzheimer's Disease
To examine the natural history and pathogenesis of parkinsonism in Alzheimer's disease, 44 subjects with clearly established senile dementia of the Alzheimer type were studied d...
α‐Synuclein Immunoisolation of Glial Inclusions from Multiple System Atrophy Brain Tissue Reveals Multiprotein Components
Immunohistochemical studies have shown that oligodendroglial inclusions in multiple system atrophy contain α-synuclein, a synaptic protein also found in Lewy bodies in Parkinson...