Publications
Explore 139 academic publications
Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation
Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unr...
Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets
The distributed brain systems associated with performance of a verbal fluency task were identified in a nondirected correlational analysis of neurophysiological data obtained wi...
Assessing the significance of focal activations using their spatial extent
Abstract Current approaches to detecting significantly activated regions of cerebral tissue use statistical parametric maps, which are thresholded to render the probability of o...
Comparing Functional (PET) Images: The Assessment of Significant Change
Statistical parametric maps (SPMs) are potentially powerful ways of localizing differences in regional cerebral activity. This potential is limited by uncertainties in assessing...
A Whole-Genome Assembly of <i>Drosophila</i>
We report on the quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it. Three independent external data so...
Polarizable Atomic Multipole Water Model for Molecular Mechanics Simulation
A new classical empirical potential is proposed for water. The model uses a polarizable atomic multipole description of electrostatic interactions. Multipoles through the quadru...
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Significance Coronaviruses such as Middle East respiratory syndrome coronavirus (MERS-CoV) cause severe respiratory distress with high fatality rates. The spike (S) glycoprotein...
Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome
Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time-varying confounders but was associated with delayed MERS...