Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Abstract

Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time-varying confounders but was associated with delayed MERS coronavirus RNA clearance. These findings highlight the challenges and importance of adjusting for baseline and time-varying confounders when estimating clinical effects of treatments using observational studies.

Keywords

MedicineCorticosteroidOdds ratioHazard ratioConfoundingConfidence intervalInternal medicineMarginal structural modelMechanical ventilationMiddle East respiratory syndrome coronavirusQuartileARDSPneumoniaCoronavirus disease 2019 (COVID-19)Lung

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Publication Info

Year: 2017
Type: article
Volume: 197
Issue: 6
Pages: 757-767
Citations: 1179
Access: Closed

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APA Style

                            
                                
                                    Yaseen M. Arabi, 
                                
                                    Yasser Mandourah, 
                                
                                    Fahad Al-Hameed
                                
                                et al.
                            
                            (2017). 
                            Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome. 
                            American Journal of Respiratory and Critical Care Medicine
                            , 197
                            (6)
                            , 757-767.
                            https://doi.org/10.1164/rccm.201706-1172oc
                        

Identifiers

DOI: 10.1164/rccm.201706-1172oc