Publications

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

Fluorine in medicinal chemistry: A review of anti-cancer agents

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

Phosphine Organocatalysis

The hallmark of nucleophilic phosphine catalysis is the initial nucleophilic addition of a phosphine to an electrophilic starting material, producing a reactive zwitterionic int...

Inside Cover: Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals (Angew. Chem. Int. Ed. 1/2020)

N-Heterocyclic carbene (NHC) organocatalysis in the presence of transition metals is a challenge because of the high affinity of NHCs for metals. In their Communication on page ...

Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

Size-Selective Lewis Acid Catalysis in a Microporous Metal-Organic Framework with Exposed Mn²⁺ Coordination Sites

Treatment of selected aldehydes and ketones with cyanotrimethylsilane in the presence of the microporous metal-organic framework Mn3[(Mn4Cl)3BTT8(CH3OH)10]2 (1, H3BTT = 1,3,5-be...

Hydroxyl radical scavenging activity of flavonoids

Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol

<b>The Factors Determining Nucleophilic Reactivities</b>

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Factors Determining Nucleophilic ReactivitiesJohn O. Edwards and Ralph G. PearsonCite this: J. Am. Chem. Soc. 1962, 84, 1, 16–24P...

Inhibitory effect of thyme and basil essential oils, carvacrol, thymol, estragol, linalool and p-cymene towards Shigella sonnei and S. flexneri

The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

Osteoprotegerin (OPG) and OPG-ligand (OPGL) potently inhibit and stimulate, respectively, osteoclast differentiation (Simonet, W.S., D.L. Lacey, C.R. Dunstan, M. Kelley, M.-S. C...