Abstract
N-Heterocyclic carbene (NHC) organocatalysis in the presence of transition metals is a challenge because of the high affinity of NHCs for metals. In their Communication on page 161, J. Mao, P. J. Walsh, and co-workers present a system for the conjugate addition of aryl iodides to enals through cooperative catalysis between an NHC and a Pd catalyst. The catalytic cycles intersect at Pd, where the two newly formed Pd−C bonds undergo reductive elimination to give a C−C bond.
Keywords
UmpolungCarbeneCatalysisArylChemistryPalladiumOrganocatalysisMedicinal chemistryConjugatePolymer chemistryOrganic chemistryCombinatorial chemistryEnantioselective synthesisAlkyl
Affiliated Institutions
Related Publications
Electron-Transfer Photoredox Catalysis: Development of a Tin-Free Reductive Dehalogenation Reaction
We report an operationally simple, tin-free reductive dehalogenation system utilizing the well-known visible-light-activated photoredox catalyst Ru(bpy)(3)Cl(2) in combination w...
Publication Info
- Year
- 2019
- Type
- paratext
- Volume
- 59
- Issue
- 1
- Pages
- 2-2
- Citations
- 985
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
985
OpenAlex
Cite This
Wenjun Yang,
Bo Ling,
Bowen Hu
et al.
(2019).
Inside Cover: Synergistic N‐Heterocyclic Carbene/Palladium‐Catalyzed Umpolung 1,4‐Addition of Aryl Iodides to Enals (Angew. Chem. Int. Ed. 1/2020).
Angewandte Chemie International Edition
, 59
(1)
, 2-2.
https://doi.org/10.1002/anie.201914768
Identifiers
- DOI
- 10.1002/anie.201914768