Obesity in children and young people: a crisis in public health
Ten per cent of the world's school-aged children are estimated to be carrying excess body fat (Fig. 1), with an increased risk for developing chronic disease. Of these overweigh...
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1,695 publications
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial
The lowering of cholesterol concentrations in individuals at high risk of cardiovascular disease improves outcome. No study, however, has assessed benefits of cholesterol loweri...
The active badge location system
A novel system for the location of people in an office environment is described. Members of staff wear badges that transmit signals providing information about their location to...
An Effective Heuristic Algorithm for the Traveling-Salesman Problem
This paper discusses a highly effective heuristic procedure for generating optimum and near-optimum solutions for the symmetric traveling-salesman problem. The procedure is base...
Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10
The Bayesian Evolutionary Analysis by Sampling Trees (BEAST) software package has become a primary tool for Bayesian phylogenetic and phylodynamic inference from genetic sequenc...
Getting a Job: A Study of Contacts and Careers.
Preface to the Second Edition Preface Acknowledgments Introduction Pt. 1: Toward Causal Models Ch. 1: Job Search and Economic Theory Ch. 2: Contacts and Their Information Ch. 3:...
Heavy metal pollution in the environment and their toxicological effects on humans
Environmental pollution of heavy metals is increasingly becoming a problem and has become of great concern due to the adverse effects it is causing around the world. These inorg...
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
We found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer's disease, b...
Oxidative stress, aging, and diseases
Reactive oxygen and nitrogen species (RONS) are produced by several endogenous and exogenous processes, and their negative effects are neutralized by antioxidant defenses. Oxida...
PhyloSuite: An integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies
Abstract Multigene and genomic data sets have become commonplace in the field of phylogenetics, but many existing tools are not designed for such data sets, which often makes th...
Self-eating and self-killing: crosstalk between autophagy and apoptosis
Apoptotic cell death is mediated by molecular pathways that culminate in the activation of a family of cysteine proteases, known as the caspases, which orchestrate the dismantli...