GeneMark.hmm: new solutions for gene finding
The number of completely sequenced bacterial genomes has been growing fast. There are computer methods available for finding genes but yet there is a need for more accurate algo...
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364 publications
Explaining the Limited Effectiveness of Legalistic “Remedies” for Trust/Distrust
Organizations frequently adopt formal rules, contracts, or other legalistic mechanisms when interpersonal trust is lacking. But recent research has shown such legalistic “remedi...
Some Concepts of Dependence
Problems involving dependent pairs of variables $(X, Y)$ have been studied most intensively in the case of bivariate normal distributions and of $2 \\times 2$ tables. This is du...
Sample size for qualitative research
Purpose Qualitative researchers have been criticised for not justifying sample size decisions in their research. This short paper addresses the issue of which sample sizes are a...
Sifting the evidence---what's wrong with significance tests? Another comment on the role of statistical methods
The findings of medical research are often met with considerable scepticism, even when they have apparently come from studies with sound methodologies that have been subjected t...
Best Estimate of Lifetime Psychiatric Diagnosis
It is important for genetic, epidemiologic, and nosological studies to determine accurate rates of lifetime psychiatric diagnoses in patient and nonpatient populations. As part ...
What do we mean by validating a prognostic model?
Prognostic models are used in medicine for investigating patient outcome in relation to patient and disease characteristics. Such models do not always work well in practice, so ...
Symmetry Breaking in Non-Abelian Gauge Theories
According to the Goldstone theorem, any manifestly covariant broken-symmetry theory must exhibit massless particles. However, it is known from previous work that such particles ...
Electrical conductivity in ionic complexes of poly(ethylene oxide)
Abstract The temperature dependence of d.c. conductivity of poly(ethylene oxide) complexes with sodium iodide and the thiocyanates of sodium, potassium and ammonium has been inv...
The National Lung Screening Trial: Overview and Study Design
The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older c...
The Lancet Countdown on health and climate change: from 25 years of inaction to a global transformation for public health
The Lancet Countdown tracks progress on health and climate change and provides an independent assessment of the health effects of climate change, the implementation of the Paris...