Chronic Lymphocytic Leukemia
Our concept of the pathogenesis of chronic lymphocytic leukemia has undergone remarkable changes during the past decade. This review addresses the latest ideas concerning the or...
Publications
Explore 25 academic publications
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25 publications
Aligning Multiple Genomic Sequences With the Threaded Blockset Aligner
We define a “threaded blockset,” which is a novel generalization of the classic notion of a multiple alignment. A new computer program called TBA (for “threaded blockset aligner...
Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome
Corticosteroid therapy in patients with MERS was not associated with a difference in mortality after adjustment for time-varying confounders but was associated with delayed MERS...
Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality*
Implementation of a severe sepsis bundle using a quality improvement feedback to modify physician behavior in the emergency department setting was feasible and was associated wi...
Predicting the Evolution of Human Influenza A
Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospe...
Gene Expression Profile in Skeletal Muscle of Type 2 Diabetes and the Effect of Insulin Treatment
Type 2 diabetes is characterized by muscle insulin resistance. Nondiabetic first-degree relatives of type 2 diabetic patients have also been reported to have insulin resistance....
Evaluating Meta-analyses in the General Surgical Literature
This critical appraisal of meta-analyses published in the general surgery literature demonstrates frequent methodologic flaws. The quality of these reports limits the validity o...
ePlant and the 3D Data Display Initiative: Integrative Systems Biology on the World Wide Web
Visualization tools for biological data are often limited in their ability to interactively integrate data at multiple scales. These computational tools are also typically limit...