Predicting the Evolution of Human Influenza A

Abstract

Eighteen codons in the HA1 domain of the hemagglutinin genes of human influenza A subtype H3 appear to be under positive selection to change the amino acid they encode. Retrospective tests show that viral lineages undergoing the greatest number of mutations in the positively selected codons were the progenitors of future H3 lineages in 9 of 11 recent influenza seasons. Codons under positive selection were associated with antibody combining site A or B or the sialic acid receptor binding site. However, not all codons in these sites had predictive value. Monitoring new H3 isolates for additional changes in positively selected codons might help identify the most fit extant viral strains that arise during antigenic drift.

Keywords

Hemagglutinin (influenza)BiologyPositive selectionGeneCladeGeneticsExtant taxonInfluenza A virusHuman influenzaStop codonVirologyVirusPhylogeneticsEvolutionary biologyCoronavirus disease 2019 (COVID-19)

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Publication Info

Year: 1999
Type: article
Volume: 286
Issue: 5446
Pages: 1921-1925
Citations: 530
Access: Closed

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APA Style

                            
                                
                                    R. Mitchell Bush, 
                                
                                    Catherine A. Bender, 
                                
                                    Kanta Subbarao
                                
                                et al.
                            
                            (1999). 
                            Predicting the Evolution of Human Influenza A. 
                            Science
                            , 286
                            (5446)
                            , 1921-1925.
                            https://doi.org/10.1126/science.286.5446.1921
                        

Identifiers

DOI: 10.1126/science.286.5446.1921