WAF1, a potential mediator of p53 tumor suppression

Keywords

BiologyEnhancerGeneTumor suppressor geneSuppression subtractive hybridizationMolecular biologyReporter geneMutantComplementary DNAGene expressioncDNA libraryCancer researchGeneticsCarcinogenesis

Affiliated Institutions

Related Publications

<b>A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode</b> .

Kristen L Murphy , Andrew P. Dennis , Jeffrey M. Rosen

ABSTRACT Approximately 40% of human breast cancers contain alterations in the tumor suppressor p53. The p53 172R‐H gain‐of‐function mutant (equivalent to the common 175R‐H human...

2000 The FASEB Journal 93 citations

Conformation-dependent phosphorylation of p53

Victor Adler , Matthew R. Pincus , Toshinari Minamoto +9 more

Phosphorylation of the p53 tumor suppressor protein is known to modulate its functions. Using bacterially produced glutathione S -transferase (GST)-p53 fusion protein and baculo...

1997 Proceedings of the National Academy o... 120 citations

Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors

Manel Esteller

Silencing of the BRCA1 gene by promoter hypermethylation occurs in primary breast and ovarian carcinomas, especially in the presence of LOH and in specific histopathologic subgr...

2000 JNCI Journal of the National Cancer I... 1201 citations

Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays.

Javed Khan , Richard H. Simon , Michael Bittner +8 more

Several forms of human sarcoma, lymphoma, and leukemia are characterized by somatically acquired chromosome translocations that result in fusion genes that encode chimeric trans...

1998 PubMed 445 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

Mark Schena , Dari Shalon , Ronald W. Davis +1 more

A high-capacity system was developed to monitor the expression of many genes in parallel. Microarrays prepared by high-speed robotic printing of complementary DNAs on glass were...

1995 Science 9537 citations

Publication Info

Year: 1993
Type: article
Volume: 75
Issue: 4
Pages: 817-825
Citations: 8349
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

WAF1, a potential mediator of p53 tumor suppression

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

8349

OpenAlex

Cite This

APA Style

                            
                                
                                    Wafik S. El‐Deiry, 
                                
                                    Takashi Tokino, 
                                
                                    Victor E. Velculescu
                                
                                et al.
                            
                            (1993). 
                            WAF1, a potential mediator of p53 tumor suppression. 
                            Cell
                            , 75
                            (4)
                            , 817-825.
                            https://doi.org/10.1016/0092-8674(93)90500-p
                        

Identifiers

DOI: 10.1016/0092-8674(93)90500-p