Abstract
Silencing of the BRCA1 gene by promoter hypermethylation occurs in primary breast and ovarian carcinomas, especially in the presence of LOH and in specific histopathologic subgroups. These findings support a role for this tumor suppressor gene in sporadic breast and ovarian tumorigenesis.
Keywords
Loss of heterozygosityMethylationCancer researchDNA methylationBiologyTumor suppressor geneOvarian cancerBreast cancerGeneMolecular biologyCarcinogenesisCancerGene expressionGeneticsAllele
Affiliated Institutions
Related Publications
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive prop...
Genetic alterations in breast cancer
Abstract The etiology of breast cancer involves a complex interplay of various factors, including genetic alterations. Many studies have been devoted to the identification and c...
Allele-specific copy number analysis of tumors
We present an allele-specific copy number analysis of the in vivo breast cancer genome. We describe a unique bioinformatics approach, ASCAT (allele-specific copy number analysis...
Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers
Abstract To identify genes that could serve as targets for novel cancer therapeutics, we used a bioinformatic analysis of microarray data comparing gene expression between norma...
Recent advances in breast cancer biology
Breast cancer remains the leading cause of death in American women 30 to 70 years of age, and research in the field of breast cancer continues at an explosive pace. Our understa...
Publication Info
- Year
- 2000
- Type
- article
- Volume
- 92
- Issue
- 7
- Pages
- 564-569
- Citations
- 1201
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1201
OpenAlex
Cite This
Manel Esteller
(2000).
Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors.
JNCI Journal of the National Cancer Institute
, 92
(7)
, 564-569.
https://doi.org/10.1093/jnci/92.7.564
Identifiers
- DOI
- 10.1093/jnci/92.7.564