Abstract
Breast cancer remains the leading cause of death in American women 30 to 70 years of age, and research in the field of breast cancer continues at an explosive pace. Our understanding of the molecular basis of familial breast cancer has advanced significantly through investigation of the tumor suppressor gene BRCA1, as has our knowledge of the role of the ATM gene and predisposition to breast cancer in ataxia-telangiectasia carriers. In addition, progress has been made in understanding the role of HER-2/neu as a prognostic factor in breast cancer. In this review, some of the recent advances in breast cancer biology that are relevant to these areas of study are highlighted.
Keywords
Breast cancerMedicineCancerAtaxia-telangiectasiaOncologyCause of deathInternal medicineDiseaseBiologyGeneticsDNA damage
Affiliated Institutions
Related Publications
Promoter Hypermethylation and BRCA1 Inactivation in Sporadic Breast and Ovarian Tumors
Silencing of the BRCA1 gene by promoter hypermethylation occurs in primary breast and ovarian carcinomas, especially in the presence of LOH and in specific histopathologic subgr...
Genetic alterations in breast cancer
Abstract The etiology of breast cancer involves a complex interplay of various factors, including genetic alterations. Many studies have been devoted to the identification and c...
Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Our study has identified key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCA2 genes. This information may improve the classification...
BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor
Mutational inactivation of BRCA1 confers a cumulative lifetime risk of breast and ovarian cancers. However, the underlying basis for the tissue-restricted tumor-suppressive prop...
Environmental exposures and mutational patterns of cancer genomes
The etiology of most human cancers is unknown. Genetic inheritance and environmental factors are thought to have major roles, and for some types of cancer, exposure to carcinoge...
Publication Info
- Year
- 1999
- Type
- review
- Volume
- 11
- Issue
- 6
- Pages
- 429-429
- Citations
- 21
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
21
OpenAlex
Cite This
Linda Schultz,
Barbara L. Weber
(1999).
Recent advances in breast cancer biology.
Current Opinion in Oncology
, 11
(6)
, 429-429.
https://doi.org/10.1097/00001622-199911000-00002
Identifiers
- DOI
- 10.1097/00001622-199911000-00002