Viral vector platforms within the gene therapy landscape

Jote Bulcha; Yi Wang; Hong Ma; Phillip W.L. Tai; Guangping Gao

doi:10.1038/s41392-021-00487-6

Keywords

Vector (molecular biology)ModalitiesGenetic enhancementViral vectorMedicineDiseaseIntensive care medicineAdverse effectBioinformaticsBiologyGenePathologyPharmacologyGenetics

Affiliated Institutions

Related Publications

Controlled drug delivery vehicles for cancer treatment and their performance

Sudipta Senapati , Arun Kumar Mahanta , Sunil Kumar +1 more

Abstract Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse ...

2018 Signal Transduction and Targeted Therapy 2049 citations

Adeno-associated virus vector as a platform for gene therapy delivery

Dan Wang , Phillip W.L. Tai , Guangping Gao

Adeno-associated virus (AAV) vectors are the leading platform for gene delivery for the treatment of a variety of human diseases. Recent advances in developing clinically desira...

2019 Nature Reviews Drug Discovery 2162 citations

RNA interference

Gregory J. Hannon

2002 Nature 3492 citations

A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice

Brian D. Brown , Alessio Cantore , Andrea Annoni +5 more

A longstanding goal for the treatment of hemophilia B is the development of a gene transfer strategy that can maintain sustained production of clotting factor IX (F.IX) in the a...

2007 Blood 248 citations

Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain

Nikisha Carty , Daniel C. Lee , Chad A. Dickey +6 more

2010 Journal of Neuroscience Methods 94 citations

Publication Info

Year: 2021
Type: review
Volume: 6
Issue: 1
Pages: 53-53
Citations: 1165
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Viral vector platforms within the gene therapy landscape

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1165

OpenAlex

Cite This

APA Style

                            
                                
                                    Jote Bulcha, 
                                
                                    Yi Wang, 
                                
                                    Hong Ma
                                
                                et al.
                            
                            (2021). 
                            Viral vector platforms within the gene therapy landscape. 
                            Signal Transduction and Targeted Therapy
                            , 6
                            (1)
                            , 53-53.
                            https://doi.org/10.1038/s41392-021-00487-6
                        

Identifiers

DOI: 10.1038/s41392-021-00487-6