Abstract

Abstract Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects. In this review, we will discuss the different types of materials used as delivery vehicles for chemotherapeutic agents and their structural characteristics that improve the therapeutic efficacy of their drugs and will describe recent scientific advances in the area of chemotherapy, emphasizing challenges in cancer treatments.

Keywords

DrugMedicineDrug deliveryChemotherapyAdverse effectCancer chemotherapyIntensive care medicinePharmacologyCancerDrug resistanceInternal medicineBiologyNanotechnology

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Publication Info

Year
2018
Type
article
Volume
3
Issue
1
Pages
7-7
Citations
2049
Access
Closed

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Cite This

Sudipta Senapati, Arun Kumar Mahanta, Sunil Kumar et al. (2018). Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduction and Targeted Therapy , 3 (1) , 7-7. https://doi.org/10.1038/s41392-017-0004-3

Identifiers

DOI
10.1038/s41392-017-0004-3
PMID
29560283
PMCID
PMC5854578

Data Quality

Data completeness: 81%