Abstract
The discovery of vascular endothelial-derived growth factor (VEGF) has revolutionized our understanding of vasculogenesis and angiogenesis during development and physiological homeostasis. Over a short span of two decades, our understanding of the molecular mechanisms by which VEGF coordinates neurovascular homeostasis has become more sophisticated. The central role of VEGF in the pathogenesis of diverse cancers and blinding eye diseases has also become evident. Elucidation of the molecular regulation of VEGF and the transformative development of multiple therapeutic pathways targeting VEGF directly or indirectly is a powerful case study of how fundamental research can guide innovation and translation. It is also an elegant example of how agnostic discovery and can transform our understanding of human disease. This review will highlight critical nodal points in VEGF biology, including recent developments in immunotherapy for cancer and multitarget approaches in neovascular eye disease.
Keywords
BiologyDiseaseComputational biologySignal transductionGeneticsEvolutionary biologyBioinformaticsInternal medicine
MeSH Terms
AnimalsHumansImmunotherapyNeoplasmsRetinal VesselsSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factors
Affiliated Institutions
Related Publications
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis,...
Angiogenesis in cancer and other diseases
Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases. Concentrated efforts in this area of research are leading to the discovery of ...
Tumor angiogenesis: past, present and the near future
The concept of treating solid tumors by inhibiting tumor angiogenesis was first articulated almost 30 years ago. For the next 10 years it attracted little scientific interest. T...
<i>flk-1</i>, an <i>flt</i>-related receptor tyrosine kinase is an early marker for endothelial cell precursors
ABSTRACT We have used RT-PCR to screen pluripotent murine embryonic stem cells to identify receptor tyrosine kinases (RTKs) potentially involved in the determination or differen...
Regulation of microRNA function in animals
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as key regulators of biological processes in animals. These small RNAs form complex networks th...
Publication Info
- Year
- 2019
- Type
- review
- Volume
- 176
- Issue
- 6
- Pages
- 1248-1264
- Citations
- 2499
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
2499
OpenAlex
76
Influential
2193
CrossRef
Cite This
Rajendra S. Apte,
Daniel S. Chen,
Napoleone Ferrara
(2019).
VEGF in Signaling and Disease: Beyond Discovery and Development.
Cell
, 176
(6)
, 1248-1264.
https://doi.org/10.1016/j.cell.2019.01.021
Identifiers
- DOI
- 10.1016/j.cell.2019.01.021
- PMID
- 30849371
- PMCID
- PMC6410740