Napoleone Ferrara

The biology of VEGF and its receptors

Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen

Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific ...

The Biology of Vascular Endothelial Growth Factor

The establishment of a vascular supply is required for organ development and differentiation as well as for tissue repair and reproductive functions in the adult1. Neovasculariz...

VEGF and the quest for tumour angiogenesis factors

Clinical applications of angiogenic growth factors and their inhibitors

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

The Vascular Endothelial Growth Factor Family: Identification of a Fourth Molecular Species and Characterization of Alternative Splicing of RNA

Vascular endothelial growth factor (VEGF) was recently identified as a secreted, direct-acting mitogen specific for vascular endothelial cells and capable of stimulating angioge...

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

The vascular endothelial growth factor (VEGF) family encompasses four polypeptides that result from alternative splicing of mRNA. We have previously demonstrated differences in ...

Vascular Endothelial Growth Factor Induces Expression of the Antiapoptotic Proteins Bcl-2 and A1 in Vascular Endothelial Cells

We examined the role of vascular endothelial growth factor (VEGF) in preventing apoptosis in primary human umbilical vein endothelial (HUVE) cells. VEGF was capable of preventin...

VEGF is required for growth and survival in neonatal mice

ABSTRACT We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP-mediated gene targeting, or administration of mFlt...

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

The hyperpermeability of tumor vessels to macromolecules, compared with normal vessels, is presumably due to vascular endothelial growth factor/vascular permeability factor (VEG...

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance

Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, has therapeutic benefit in animal models of coronary or limb ischemia. However, the hemodynamic eff...