Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma

Abstract

In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials.

Keywords

MedicineARDSConvalescent plasmaConvalescenceTiterPneumoniaMechanical ventilationCoronavirus disease 2019 (COVID-19)Internal medicineIntensive care medicineImmunologyEmergency medicineDiseaseAntibodyInfectious disease (medical specialty)Lung

MeSH Terms

AdultAgedAntibodiesNeutralizingAntibodiesViralAntiviral AgentsBetacoronavirusBlood DonorsCOVID-19Coronavirus InfectionsCritical IllnessFemaleGlucocorticoidsHumansImmunizationPassiveImmunoglobulin GImmunoglobulin MMaleMethylprednisoloneMiddle AgedOrgan Dysfunction ScoresPandemicsPneumoniaViralRespiratory Distress SyndromeSARS-CoV-2COVID-19 Serotherapy

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Publication Info

Year: 2020
Type: article
Volume: 323
Issue: 16
Pages: 1582-1582
Citations: 2404
Access: Closed

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APA Style

                            
                                
                                    Chenguang Shen, 
                                
                                    Zhaoqin Wang, 
                                
                                    Fang Zhao
                                
                                et al.
                            
                            (2020). 
                            Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. 
                            JAMA
                            , 323
                            (16)
                            , 1582-1582.
                            https://doi.org/10.1001/jama.2020.4783
                        

Identifiers

DOI: 10.1001/jama.2020.4783
PMID: 32219428
PMCID: PMC7101507

Data Quality

Data completeness: 86%