Antigenic Cross‐Reactivity between Severe Acute Respiratory Syndrome–Associated Coronavirus and Human Coronaviruses 229E and OC43

Abstract

Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.

Keywords

Cross-reactivityAntigenVirologyCoronavirusAntibodyImmunofluorescenceWestern blotTiterRespiratory systemBiologyImmunologyCoronavirus disease 2019 (COVID-19)MedicineCross reactionsPathologyGeneInfectious disease (medical specialty)Disease

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Publication Info

Year: 2005
Type: article
Volume: 191
Issue: 12
Pages: 2033-2037
Citations: 180
Access: Closed

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APA Style

                            
                                
                                    Chi‐Ming Che, 
                                
                                    Li‐wen Qiu, 
                                
                                    Zhiyong Liao
                                
                                et al.
                            
                            (2005). 
                            Antigenic Cross‐Reactivity between Severe Acute Respiratory Syndrome–Associated Coronavirus and Human Coronaviruses 229E and OC43. 
                            The Journal of Infectious Diseases
                            , 191
                            (12)
                            , 2033-2037.
                            https://doi.org/10.1086/430355
                        

Identifiers

DOI: 10.1086/430355