Abstract
Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
Keywords
Cytokine stormPathogenesisCytokineStormCoronavirus disease 2019 (COVID-19)DiseaseMedicineImmune systemCoronavirusSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologyMechanism (biology)Infectious disease (medical specialty)PathologyGeographyMeteorology
MeSH Terms
Anti-Inflammatory AgentsBetacoronavirusCOVID-19Coronavirus InfectionsCritical IllnessCytokine Release SyndromeHumansPandemicsPneumoniaViralSARS-CoV-2
Affiliated Institutions
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Publication Info
- Year
- 2020
- Type
- review
- Volume
- 80
- Issue
- 6
- Pages
- 607-613
- Citations
- 2796
- Access
- Closed
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Cite This
Qing Ye,
Bili Wang,
Jianhua Mao
(2020).
The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.
Journal of Infection
, 80
(6)
, 607-613.
https://doi.org/10.1016/j.jinf.2020.03.037
Identifiers
- DOI
- 10.1016/j.jinf.2020.03.037
- PMID
- 32283152
- PMCID
- PMC7194613